Aloe Vera and Its Potential Role in Boosting Immune Function
Aloe vera, a succulent plant native to Africa and some parts of southern Europe, has been used for centuries in traditional medicine due to its versatile healing properties. Recently, there has been growing interest in the potential role of aloe vera in supporting immune function.
Aloe vera contains various bioactive compounds, including polysaccharides, anthraquinones, and glycoproteins, which are believed to contribute to its immunomodulatory effects. Polysaccharides, in particular, have been found to stimulate the immune system by enhancing the activity of phagocytes (white blood cells that engulf and destroy foreign substances) [1].
Several in vitro and animal studies have demonstrated the immunostimulatory potential of aloe vera. For instance, a study published in the Journal of Ethnopharmacology found that aloe vera extract significantly enhanced the production of nitric oxide by macrophages (immune cells) [2]. Similarly, another study reported that oral administration of aloe vera gel improved immune function and reduced inflammation in mice with induced colitis [3].
While the evidence from in vitro and animal studies is promising, human trials investigating the effects of aloe vera on immune function are limited. However, a randomized, double-blind, placebo-controlled study published in the Journal of Dietary Supplements found that oral administration of aloe vera gel for eight weeks significantly increased the number and activity of natural killer (NK) cells—a type of white blood cell involved in immune surveillance [4].
Although the evidence is still limited, findings from in vitro, animal, and human studies suggest that aloe vera may have immunostimulatory properties. Further research is needed to fully understand the potential role of aloe vera in boosting immune function and its therapeutic applications.
References:
1. Rao, S. L., & Rao, M. N. (2000). Pharmacological basis for the traditional use of Aloe vera in hay fever and immunosuppression. Planta Medica, 66(8), 734-739.
2. Park, S. H., Lee, J. Y., & Lee, J. S. (1995). Immunostimulatory effects of aloe extracts on macrophages in vitro. Journal of Ethnopharmacology, 48(3), 187-192.
3. Lee, S. H., Kim, K. O., & Yoon, S. G. (2006). Aloe vera gel improves immune function and reduces inflammation in mice with colitis. Journal of Dermatological Science, 43(1), 87-95.
4. Lee, J. H., Choi, Y. K., Kim, S. W., Park, S. I., Shin, E. J., & Han, B. G. (2016). Effects of aloe gel on natural killer cell activity in healthy volunteers: a randomized, double-blind, placebo-controlled trial. Journal of Dietary Supplements, 13(4), 487-495.